Do you have a secretary work background? Now you can take your skills and apply it to an online position. Tons of companies and people who are successful online use virtual assistants to keep their days in order. The best sites to get these jobs tend to be freelance sites.
I'm going to also talk about another work at home opportunity called a search engine assessor. This is similar to the Virtual Assistant because you still have a boss, but you can work from home. Companies like LionBridge hire work from homers to find unqualified pages in search results. If it sounds like something you'd be interested in check out LionBridge or LeapForce.